CAJ | 학술논문

目的：研究探讨血培养中病原菌的分布情况，并分析其耐药性。方法整群选取临床送检的5010份血标本为研究对象，做常规血培养，并对培养阳性标本中的病原菌进行分离和鉴别，统计不同菌株的耐药情况。结果5010份血液标本经血培养共获得病原菌498株，血培养阳性率为9.9%。其中，革兰氏阴性菌检出率最高，为51.2%，常见菌株对亚胺培南和美罗培南耐药性较低，革兰氏阳性菌(38.2%)则对替加环素、万古霉素、利奈唑胺均无显著耐药性，常见真菌(10.6%)对大部分药物耐药性都比较低。结论血培养阳性的病原菌以革兰氏阴性菌为主，对多数常见药物都有耐药性，临床治疗过程中要以病原菌鉴别、耐药结果为实验依据提高用药合理性。
목적：연구탐토혈배양중병원균적분포정황，병분석기내약성。방법정군선취림상송검적5010빈혈표본위연구대상，주상규혈배양，병대배양양성표본중적병원균진행분리화감별，통계불동균주적내약정황。결과5010빈혈액표본경혈배양공획득병원균498주，혈배양양성솔위9.9%。기중，혁란씨음성균검출솔최고，위51.2%，상견균주대아알배남화미라배남내약성교저，혁란씨양성균(38.2%)칙대체가배소、만고매소、리내서알균무현저내약성，상견진균(10.6%)대대부분약물내약성도비교저。결론혈배양양성적병원균이혁란씨음성균위주，대다수상견약물도유내약성，림상치료과정중요이병원균감별、내약결과위실험의거제고용약합이성。
Objective To investigate the distribution of pathogens in blood cultures and analyze their drug resistance. Methods Selected 5010 clinical inspection blood samples for the study, and gave routine blood culture, and culture-positive pathogens were separated and identified, and gave statistical analysis of drug resistance of different strains. Results From the 5010 blood samples of blood cultures, 498 pathogens were obtained, and positive rate of blood culture was 9.9%. Among them, the detection rate of Gram-negative bacteria was highest, accounted for 51.2%. The drug resistant of common strains to imipenem and meropenem were low, and the drug resistence of Gram-positive bacteria (38.2%) to tigecycline, vancomycin and linezolid was not significant, and the drug resistance of common fungus (10.6%) to most drugs are relatively low. Conclusion Blood culture-positive pathogens are mainly Gram-negative bacteria, and have drug resistance to most common drugs. And clinical treatment should be according to the results of identification and drug resistance of the pathogen, in order to improve the reasonability of drug treatment.