CAJ | 학술논문

目的：探究奥美拉唑对口服拜阿司匹林引起的胃肠道反应的防治效果。方法随机选取该院2012年10月—2013年5月期间收治的60例老年心血管疾病患者的相关临床资料综合分析,并将其按照就诊时间随机分为观察组和对照组,两组患者均采用口服小剂量拜阿司匹林治疗,剂量为100 mg/d。因服药后,患者出现了不同程度的胃肠道反应症状,将观察组患者予以质子泵抑制剂奥美拉唑口服：20 mg/次,2次/d,对照组则不予奥美拉唑或其他治疗措施,比较2组患者的临床疗效。结果观察组使用口服奥美拉唑肠溶片治疗,对拜阿司匹林引起的胃肠道反应方面起到了明显改善作用,且减轻了患者痛苦,观察组患者有效28例,有效率为93.3%,对照组患者有效仅18例,有效率为60.0%,观察组临床总显效率明显高于对照组,组间比较差异有统计学意义(P<0.05)且观察组症状改善时间为(6.14±1.23) d,对照组时间为(10.57±2.39) d,观察组在患者症状改善时间方面优于对照组。结论采用奥美拉唑治疗对口服拜阿司匹林引起的胃肠道反应方面的效果,具有较高的临床价值。
목적：탐구오미랍서대구복배아사필림인기적위장도반응적방치효과。방법수궤선취해원2012년10월—2013년5월기간수치적60례노년심혈관질병환자적상관림상자료종합분석,병장기안조취진시간수궤분위관찰조화대조조,량조환자균채용구복소제량배아사필림치료,제량위100 mg/d。인복약후,환자출현료불동정도적위장도반응증상,장관찰조환자여이질자빙억제제오미랍서구복：20 mg/차,2차/d,대조조칙불여오미랍서혹기타치료조시,비교2조환자적림상료효。결과관찰조사용구복오미랍서장용편치료,대배아사필림인기적위장도반응방면기도료명현개선작용,차감경료환자통고,관찰조환자유효28례,유효솔위93.3%,대조조환자유효부18례,유효솔위60.0%,관찰조림상총현효솔명현고우대조조,조간비교차이유통계학의의(P<0.05)차관찰조증상개선시간위(6.14±1.23) d,대조조시간위(10.57±2.39) d,관찰조재환자증상개선시간방면우우대조조。결론채용오미랍서치료대구복배아사필림인기적위장도반응방면적효과,구유교고적림상개치。
Objective To explore the preventive effect of omeprazole on gastrointestinal reaction caused by oral administration of aspirin. Methods The relevant clinical data comprehensive analysis method of 60 cases of disease of patients admitted during the period from October 2012 to May 2013 in our department aged cardiovascular, and in accordance with the time of treatment were randomly divided into observation group and control group, two patients were treated with low-dose oral aspirin therapy, the dose of 100 mg/d. Because after medication, patients had gastrointestinal symptoms in different degree, the patients in observation group were given omeprazole orally:20 mg/times, 2 times/d, while the control group has no omeprazole or other treatment, compared the clinical efficacy of 2 groups. Results Observation group use omeprazole enteric coated tablets in the treatment, the aspirin caused gastrointestinal reactions to significantly improve and reduce the pain of patients, in the observation group were 28 cases were ef-fective, efficient 93.3%, the patients in the control group only 18 cases, effective 60.0%in the observed group, the clinical total ef-fective rate was significantly higher than that of the control group, the difference between, the two groups has statistical signifi-cance (P<0.05) and observation group symptom improvement time (6.14±1.23) d, the control group, the time for (10.57±2.39) d, the observation group in patients with symptoms improve time were better than the control group. Conclusion Omeprazole in the treat-ment of gastrointestinal reaction of oral aspirin induced side effect, with a high clinical value.