中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2015年
23期
34-35
,共2页
进展期宫颈癌%栓塞%动脉介入%PICC新辅助化疗%疗效%预后
進展期宮頸癌%栓塞%動脈介入%PICC新輔助化療%療效%預後
진전기궁경암%전새%동맥개입%PICC신보조화료%료효%예후
Advanced cervical cancer%Embolization%Arterial interventional%PICC neoadjuvant chemotherapy%Efficacy%Prognosis
目的：探讨和研究子宫动脉介入栓塞联合静脉用药化疗对于局部进展期宫颈癌治疗方法,并对该方法的短期治疗效果与远期预后效果进行评价。方法整群选取该院自2013年6月—2014年2月期间收治的Ⅰb~Ⅱb期宫颈癌患者共110例,按随机原则把其分为观察组60例和对照组50例。对照组应用双侧子宫动脉介入栓塞进行治疗,观察组通过PICC在术前实施化疗。手术结束后对两组短期疗效进行比较比,并进行12个月随访,对患者的远期复发率和生存率进行对比。结果在结束化疗2周后,均经盆腔B超和CT检查,观察组患者的瘤体平均最大直径为(2.6±0.5)mm,明显小于对照组(3.1±0.7) mm,两组患者治疗后的瘤体直径直径对比,存在明显的差异(t=5.082,P<0.05)。此外,观察组患者的总有效率为81.6%,明显高于对照组(70.0%),该两组患者的总有效率对比,差异有统计学意义(χ2=7.316,P<0.05)。结论术前运用子宫动脉介入栓塞,结合DDP+TAX的治疗,要比仅仅运用PICC静脉用药方案治疗的短期疗效明显提升,而且对进行宫颈癌根治手术也非常有利,不过其对患者邻近的非靶向器官损害和影响要特别警惕。
目的：探討和研究子宮動脈介入栓塞聯閤靜脈用藥化療對于跼部進展期宮頸癌治療方法,併對該方法的短期治療效果與遠期預後效果進行評價。方法整群選取該院自2013年6月—2014年2月期間收治的Ⅰb~Ⅱb期宮頸癌患者共110例,按隨機原則把其分為觀察組60例和對照組50例。對照組應用雙側子宮動脈介入栓塞進行治療,觀察組通過PICC在術前實施化療。手術結束後對兩組短期療效進行比較比,併進行12箇月隨訪,對患者的遠期複髮率和生存率進行對比。結果在結束化療2週後,均經盆腔B超和CT檢查,觀察組患者的瘤體平均最大直徑為(2.6±0.5)mm,明顯小于對照組(3.1±0.7) mm,兩組患者治療後的瘤體直徑直徑對比,存在明顯的差異(t=5.082,P<0.05)。此外,觀察組患者的總有效率為81.6%,明顯高于對照組(70.0%),該兩組患者的總有效率對比,差異有統計學意義(χ2=7.316,P<0.05)。結論術前運用子宮動脈介入栓塞,結閤DDP+TAX的治療,要比僅僅運用PICC靜脈用藥方案治療的短期療效明顯提升,而且對進行宮頸癌根治手術也非常有利,不過其對患者鄰近的非靶嚮器官損害和影響要特彆警惕。
목적：탐토화연구자궁동맥개입전새연합정맥용약화료대우국부진전기궁경암치료방법,병대해방법적단기치료효과여원기예후효과진행평개。방법정군선취해원자2013년6월—2014년2월기간수치적Ⅰb~Ⅱb기궁경암환자공110례,안수궤원칙파기분위관찰조60례화대조조50례。대조조응용쌍측자궁동맥개입전새진행치료,관찰조통과PICC재술전실시화료。수술결속후대량조단기료효진행비교비,병진행12개월수방,대환자적원기복발솔화생존솔진행대비。결과재결속화료2주후,균경분강B초화CT검사,관찰조환자적류체평균최대직경위(2.6±0.5)mm,명현소우대조조(3.1±0.7) mm,량조환자치료후적류체직경직경대비,존재명현적차이(t=5.082,P<0.05)。차외,관찰조환자적총유효솔위81.6%,명현고우대조조(70.0%),해량조환자적총유효솔대비,차이유통계학의의(χ2=7.316,P<0.05)。결론술전운용자궁동맥개입전새,결합DDP+TAX적치료,요비부부운용PICC정맥용약방안치료적단기료효명현제승,이차대진행궁경암근치수술야비상유리,불과기대환자린근적비파향기관손해화영향요특별경척。
Objective To explore the short-term therapeutic effect and long-term prognosis of bilateral uterine artery embolization chemotherapy in the treatment of patients with locally advanced cervical cancer. Methods 110 patients with locally cervical cancer in stageⅠb-Ⅱb admitted to our hospital during June 2013 and February 2014 were randomly divided into observation group (n=60) and control group (n=50). Bilateral uterine artery embolization chemotherapy and chemotherapy via peripherally inserted cen-tral catheter were performed in them respectively. The short-term efficacies were compared and all the patients were followed-up 12 months for comparison of the long-term recurrence rate and survival rate. Results 2 weeks after chemotherapy, CT and type "B" ultrasonic scan of pelvis were conducted, which showed that the even diameters of the tumors was shorter, and the total effi-ciency was higher in the observation group than in the control group, which were(2.6±0.5)mm vs(3.1±0.7)mm and 81.6% vs 70.0%, and the differences were statistically significant(t=5.082, P<0.05;χ2=7.316,P<0.05). Conclusion Compared with chemother-apy (DDP+TAX) via peripherally inserted central catheter, bilateral uterine artery embolization chemotherapy (DDP+TAX) has bet-ter short-term therapeutic effect and can contribute to radical hysterectomy if its damage to nearby normal organs was controlled.
