华西药学杂志
華西藥學雜誌
화서약학잡지
WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
2001年
1期
23-24
,共2页
目的：对紫杉醇脂质体的工艺研究和含量测定方法进行考察，并评价其质量。方法：用逆相蒸发法制备紫杉醇脂质体，并对其形态学、包封率和pH值等性质进行了研究。结果：紫杉醇脂质体平均粒径为379 nm,包封率为 98.08%, pH 7.16。结论：选择逆相蒸发法优化工艺制备紫杉醇脂质体可行，为开发紫杉醇新型静脉注射制剂提供了实验依据。
目的：對紫杉醇脂質體的工藝研究和含量測定方法進行攷察，併評價其質量。方法：用逆相蒸髮法製備紫杉醇脂質體，併對其形態學、包封率和pH值等性質進行瞭研究。結果：紫杉醇脂質體平均粒徑為379 nm,包封率為 98.08%, pH 7.16。結論：選擇逆相蒸髮法優化工藝製備紫杉醇脂質體可行，為開髮紫杉醇新型靜脈註射製劑提供瞭實驗依據。
목적：대자삼순지질체적공예연구화함량측정방법진행고찰，병평개기질량。방법：용역상증발법제비자삼순지질체，병대기형태학、포봉솔화pH치등성질진행료연구。결과：자삼순지질체평균립경위379 nm,포봉솔위 98.08%, pH 7.16。결론：선택역상증발법우화공예제비자삼순지질체가행，위개발자삼순신형정맥주사제제제공료실험의거。
OBJECTIVE:To study the preparation of paclitaxel entrapped liposomes (LTAX) and evaluate its quality.METHODS:The liposomes were prepared by reverse-phase evaporation method (REV) .The morphology of LTAX, the entrapment efficiency and the pH were investigated.RESULTS:The liposomes were spherical with mean size of 379 nm and the extent of entrapment of the LTAX was 98.08%.The pH was 7.16.CONCLUSION:The technology of preparation of paclitaxel liposomes is practicable and successful.
