CAJ | 학술논문

目的：探讨普伐他汀对兔动脉粥样硬化（AS）斑块稳定性及血清脂蛋白相关磷脂酶A2（Lp-PLA2）表达的影响。方法取大白兔24只，随机分为甲、乙、丙三组，每组8只。甲组不造模，乙、丙组采用球囊拉伤法制造AS模型，丙组给予普伐他汀干预，然后观察其病理改变及血清Lp-PLA2表达情况。结果与甲组比较，第5、10周乙、丙组大白兔血清Lp-PLA2水平显著增高，差异均有统计学意义（P＜0.05），且第10周乙组大白兔血清Lp-PLA2水平增高更为明显。与乙组比较，第5、10周丙组大白兔血清Lp-PLA2水平均明显下降，差异均有统计学意义（P＜0.05）。第5、10周乙组大白兔血清Lp-PLA2水平均显著高于实验前，差异均有统计学意义（P＜0.01）。第5、10周丙组大白兔血清Lp-PLA2水平略高于实验前。普伐他汀干预后AS斑块的病理学形态、结构均发生改变，斑块结构更加趋于稳定。结论普伐他汀能降低AS动物的Lp-PLA2水平，促进斑块稳定。
목적：탐토보벌타정대토동맥죽양경화（AS）반괴은정성급혈청지단백상관린지매A2（Lp-PLA2）표체적영향。방법취대백토24지，수궤분위갑、을、병삼조，매조8지。갑조불조모，을、병조채용구낭랍상법제조AS모형，병조급여보벌타정간예，연후관찰기병리개변급혈청Lp-PLA2표체정황。결과여갑조비교，제5、10주을、병조대백토혈청Lp-PLA2수평현저증고，차이균유통계학의의（P＜0.05），차제10주을조대백토혈청Lp-PLA2수평증고경위명현。여을조비교，제5、10주병조대백토혈청Lp-PLA2수평균명현하강，차이균유통계학의의（P＜0.05）。제5、10주을조대백토혈청Lp-PLA2수평균현저고우실험전，차이균유통계학의의（P＜0.01）。제5、10주병조대백토혈청Lp-PLA2수평략고우실험전。보벌타정간예후AS반괴적병이학형태、결구균발생개변，반괴결구경가추우은정。결론보벌타정능강저AS동물적Lp-PLA2수평，촉진반괴은정。
Objective To investigate the influence of pravastatin on the atherosclerotic plaque (AS) stability and serum Lp-PLA2 expression in rabbit. Methods 24 rabbits were randomly divided into the group A,B and C,8 cases in each group. The group A was non-model. The group B and C adopted the balloon pulling injury method for establishing the AS model. Then the pathological changes and serum Lp-PLA2 expression were observed. Results Compared with the group A,serum Lp-PLA2 levels at 5,10 weeks in the group B and C were increased significantly,the differences were statistically significant(P<0.05),moreover the increase of serum Lp-PLA2 level at 10 weeks in the group B was more obvious. Compared with the group B ,the serum Lp-PLA2 levels at 5,10 weeks in the group C was significantly decreased,the difference was statistically significant(P<0.05). The serum Lp-PLA2 levels at 5,10 weeks in the group B were significantly higher than those before experiment,the difference was sta-tistically significant(P<0.01). The serum Lp-PLA2 levels at 5,10 weeks in the group C were slightly higher than those before ex-periment. The pathological morphology and structure of AS plaque after pravastatin intervention were changed and the plaque structure trended to be more stable. Conclusion Pravastatin can reduce Lp-PLA2 level in the AS animal and promotes the AS plaque stability.