CAJ | 학술논문

目的：探讨肿瘤标志物CA199联合CA242测定用于纠正高胆红素血症对良性疾病患者CA199检测的假阳性结果。方法对78例良性肝胆疾病伴有高胆红素血症患者血清进行肿瘤标志物AFP、CEA、CA199、CA125及CA153的浓度检测，CA199检测为阳性的标本，增加CA242测定并在临床有效治疗无高胆红素血症后复查CA199和CA242。结果高胆红素血症对良性疾病患者CA199的测定影响较大，对CA242影响较小，经治疗无高胆红素血症后复查CA199阳性率显著下降，由治疗前76.9%降低到治疗后5.13%。结论CA242可以纠正CA199在高胆红素血症影响下良性疾病的假阳性结果，对于良恶性疾病的鉴别有重要意义。
목적：탐토종류표지물CA199연합CA242측정용우규정고담홍소혈증대량성질병환자CA199검측적가양성결과。방법대78례량성간담질병반유고담홍소혈증환자혈청진행종류표지물AFP、CEA、CA199、CA125급CA153적농도검측，CA199검측위양성적표본，증가CA242측정병재림상유효치료무고담홍소혈증후복사CA199화CA242。결과고담홍소혈증대량성질병환자CA199적측정영향교대，대CA242영향교소，경치료무고담홍소혈증후복사CA199양성솔현저하강，유치료전76.9%강저도치료후5.13%。결론CA242가이규정CA199재고담홍소혈증영향하량성질병적가양성결과，대우량악성질병적감별유중요의의。
Objective To investigate the combined determination of tumor markers CA199 and CA242 in correcting the false posi-tive result, which is caused by hyperbilirubinemia, after CA199 detection in patients with benign disease. Methods The detection of tumor markers AFP, CEA, CA199, CA125, CA153 in serum was conducted in 78 patients with benign hepatobiliary diseases combined with hyperbilirubinemia, and for those specimens which obtained positive results, CA242 detection was performed addi-tionally and re-determination of CA199 and CA242 after hyperbilirubinemia was treated effectively was done. Results Hyper-bilirubinemia had more influence on CA199 detection but little on CA242 detection in patients with benign disease. Re-determi-nation demonstrated that positive rate of CA199 detection was significantly lower after hyperbilirubinemia disappeared than that before, 5.13% vs 76.9%. Conclusion For patients with benign disease, combined determination of tumor markers CA199 and CA242 can correct the false positive results after CA199 detection which may be influenced by hyperbilirubinemia, therefore it is of great significance to the differentiation of benign and malignant diseases.