中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
24期
59-60,68
,共3页
姚辉洁%黄银兰%李洋洋%吕杨%洪权%杜婧
姚輝潔%黃銀蘭%李洋洋%呂楊%洪權%杜婧
요휘길%황은란%리양양%려양%홍권%두청
高位结肠透析%大鼠%方法
高位結腸透析%大鼠%方法
고위결장투석%대서%방법
High colon dialysis%Rat%Method
目的：建立大鼠高位结肠透析方法，探析该方法对急性肾功能衰竭大鼠的治疗效果。方法健康雄性SD大鼠15只，随机分为正常组、模型组和治疗组（各5只），正常组不作任何处理，模型组和治疗组甘油诱导建立急性肾功能衰竭模型，治疗组给予高位结肠透析治疗，观察各组血肌酐、尿素氮水平变化。结果模型组和治疗组的血肌酐、尿素氮水平较正常组明显升高，差异具有统计学意义（P<0.05）；治疗组的血肌酐值（230.98±95.51）μmol/L较模型组（317.90±77.63）μmol/L明显降低(P<0.05)；治疗组血尿素氮水平（35.00±11.93）mmol/L较模型组（52.53±21.5）mmol/L也有明显降低趋势，差异无统计学意义（P>0.05）。结论成功建立了大鼠高位结肠透析方法，期望为后期实验利用动物实验进行高位结肠透析的方法改进和机制研究奠定基础。
目的：建立大鼠高位結腸透析方法，探析該方法對急性腎功能衰竭大鼠的治療效果。方法健康雄性SD大鼠15隻，隨機分為正常組、模型組和治療組（各5隻），正常組不作任何處理，模型組和治療組甘油誘導建立急性腎功能衰竭模型，治療組給予高位結腸透析治療，觀察各組血肌酐、尿素氮水平變化。結果模型組和治療組的血肌酐、尿素氮水平較正常組明顯升高，差異具有統計學意義（P<0.05）；治療組的血肌酐值（230.98±95.51）μmol/L較模型組（317.90±77.63）μmol/L明顯降低(P<0.05)；治療組血尿素氮水平（35.00±11.93）mmol/L較模型組（52.53±21.5）mmol/L也有明顯降低趨勢，差異無統計學意義（P>0.05）。結論成功建立瞭大鼠高位結腸透析方法，期望為後期實驗利用動物實驗進行高位結腸透析的方法改進和機製研究奠定基礎。
목적：건립대서고위결장투석방법，탐석해방법대급성신공능쇠갈대서적치료효과。방법건강웅성SD대서15지，수궤분위정상조、모형조화치료조（각5지），정상조불작임하처리，모형조화치료조감유유도건립급성신공능쇠갈모형，치료조급여고위결장투석치료，관찰각조혈기항、뇨소담수평변화。결과모형조화치료조적혈기항、뇨소담수평교정상조명현승고，차이구유통계학의의（P<0.05）；치료조적혈기항치（230.98±95.51）μmol/L교모형조（317.90±77.63）μmol/L명현강저(P<0.05)；치료조혈뇨소담수평（35.00±11.93）mmol/L교모형조（52.53±21.5）mmol/L야유명현강저추세，차이무통계학의의（P>0.05）。결론성공건립료대서고위결장투석방법，기망위후기실험이용동물실험진행고위결장투석적방법개진화궤제연구전정기출。
Objective To establish the high colonic dialysis and observe its efficacy in treating acute renal failure in rats. Methods 15 healthy male SD rats were randomized into normal group, model group and treatment group with 5 in each group. The normal group was untreated, while acute renal failure model were established in the model group and treatment group followed by high colonic dialysis performed in the treatment group. The changes of serum creatinine and blood urea nitrogen levels were observed in all the three groups. Results The serum creatinine and blood urea nitrogen levels were higher in the model group and treatment group than in the normal group, and the differences were statistically significant, P<0.05; the serum creatinine level was lower in the treatment group than in the normal group, 230.98±95.51μmol/L vs 317.90±77.63μmol/L, and the difference was statistically significant, P<0.05;the blood urea nitrogen level was lower in the treatment group than in the normal group, 35.00±11.93 mmol/L vs 52.53±21.5 mmol/L, but the difference was not statistically significant, P﹥0.05. Conclusion Preliminary establishment of high colon dialysis in rat is realized, which may lay the foundation for the future improvement of high colon dialysis upon animal exper-iment, and for the study on its mechanism.
