中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
24期
18-19
,共2页
HER-2过表达%三阴性乳腺癌%恶性程度%转移
HER-2過錶達%三陰性乳腺癌%噁性程度%轉移
HER-2과표체%삼음성유선암%악성정도%전이
HER-2 over-expression%Triple-negative breast cancer%Degree of malignancy%Metastasis
目的：比较病理诊断HER-2过表达乳腺癌与三阴性乳腺癌的特征。方法整群选取该院2013年1月-2015年5月收治182例浸润性乳腺癌患者进行研究，根据免疫组化法检测结果分为A组(HER-2过表达乳腺癌组)与B组(三阴性乳腺癌组)，对比两组淋巴结转移、组织学分级、AJCC分期情况。结果 B组淋巴结转移率达到69.6%，明显高于A组47.4%，差异有统计学意义(P<0.05）；且B组淋巴结转移数量≥10枚所占百分率，也明显高于A组，差异有统计学意义(P<0.05）。A组中3级患者所占百分率为36.8%，明显低于B组中65.2%，差异有统计学意义(P<0.05）。结论三阴性乳腺癌及HER-2过表达乳腺癌均以浸润性导管癌为主，前者三阴侵袭性更强，恶性程度更高，易发生淋巴结转移，与HER-2过表达乳腺癌相比预后更难以保证，需引起重视。
目的：比較病理診斷HER-2過錶達乳腺癌與三陰性乳腺癌的特徵。方法整群選取該院2013年1月-2015年5月收治182例浸潤性乳腺癌患者進行研究，根據免疫組化法檢測結果分為A組(HER-2過錶達乳腺癌組)與B組(三陰性乳腺癌組)，對比兩組淋巴結轉移、組織學分級、AJCC分期情況。結果 B組淋巴結轉移率達到69.6%，明顯高于A組47.4%，差異有統計學意義(P<0.05）；且B組淋巴結轉移數量≥10枚所佔百分率，也明顯高于A組，差異有統計學意義(P<0.05）。A組中3級患者所佔百分率為36.8%，明顯低于B組中65.2%，差異有統計學意義(P<0.05）。結論三陰性乳腺癌及HER-2過錶達乳腺癌均以浸潤性導管癌為主，前者三陰侵襲性更彊，噁性程度更高，易髮生淋巴結轉移，與HER-2過錶達乳腺癌相比預後更難以保證，需引起重視。
목적：비교병리진단HER-2과표체유선암여삼음성유선암적특정。방법정군선취해원2013년1월-2015년5월수치182례침윤성유선암환자진행연구，근거면역조화법검측결과분위A조(HER-2과표체유선암조)여B조(삼음성유선암조)，대비량조림파결전이、조직학분급、AJCC분기정황。결과 B조림파결전이솔체도69.6%，명현고우A조47.4%，차이유통계학의의(P<0.05）；차B조림파결전이수량≥10매소점백분솔，야명현고우A조，차이유통계학의의(P<0.05）。A조중3급환자소점백분솔위36.8%，명현저우B조중65.2%，차이유통계학의의(P<0.05）。결론삼음성유선암급HER-2과표체유선암균이침윤성도관암위주，전자삼음침습성경강，악성정도경고，역발생림파결전이，여HER-2과표체유선암상비예후경난이보증，수인기중시。
Objective To compare the pathological characteristics between HER-2 over-expression breast cancer and triple-nega-tive breast cancer (TNBC). Methods 182 patients with invasive breast cancer admitted to the hospital between January 2013 and May 2015 were studied and divided into group A (HER-2 over-expression breast cancer group) and group B (TNBC group) ac-cording to the detection results of immunohistochemical assay. The lymph node metastasis, histological grade and the status of A-JCC staging of the two groups were compared. Results The rate of lymph node metastasis in group B reached 69.6% which was significantly higher than 47.4% in group A, and the difference was statistically significant (P<0.05); and the percentage of the number of lymph node metastasis equal to or more than 10 in group B was also significantly higher than that in group A and the difference was statistically significant (P<0.05). In group A, the percentage of patients of level three was 36.8%which was signifi-cantly lower than 65.2% in group B and the difference was statistically significant (P<0.05). Conclusion The TNBC and HER-2 over-expression breast cancer mainly are infiltrating ductal carcinoma. The triple negative invasion of the former is stronger with higher degree of malignancy and is prone to appear lymph node metastasis. Compared with HER-2 over-expression breast cancer, its prognosis is more difficult to guarantee, so attention should be paid to it.
