现代电子技术
現代電子技術
현대전자기술
Modern Electronics Technique
2015年
17期
124-126
,共3页
延迟效应%网络重构%信息论%基因表达数据
延遲效應%網絡重構%信息論%基因錶達數據
연지효응%망락중구%신식론%기인표체수거
delayed effect%network reconfiguration%information theory%gene expression data
大量调控网络重构的模型和方法被研究,但是数据大小对算法精度的影响问题涉及很少.通过研究数据尺寸大小对延迟信息论方法构建基因调控网络精度的影响,表明基因调控网络构建的精度会在一定数据尺寸规模下达到一个稳态.为了克服互信息的一些缺点,引入了多时延互信息值计算两个基因之间的调控关系,构建的基因调控网络取得了很好的查全率和查准率.并用真实的生物分子网络进行测试,实验表明,基于多时延的策略在构建基因调控网络中扮演了一个重要角色.
大量調控網絡重構的模型和方法被研究,但是數據大小對算法精度的影響問題涉及很少.通過研究數據呎吋大小對延遲信息論方法構建基因調控網絡精度的影響,錶明基因調控網絡構建的精度會在一定數據呎吋規模下達到一箇穩態.為瞭剋服互信息的一些缺點,引入瞭多時延互信息值計算兩箇基因之間的調控關繫,構建的基因調控網絡取得瞭很好的查全率和查準率.併用真實的生物分子網絡進行測試,實驗錶明,基于多時延的策略在構建基因調控網絡中扮縯瞭一箇重要角色.
대량조공망락중구적모형화방법피연구,단시수거대소대산법정도적영향문제섭급흔소.통과연구수거척촌대소대연지신식론방법구건기인조공망락정도적영향,표명기인조공망락구건적정도회재일정수거척촌규모하체도일개은태.위료극복호신식적일사결점,인입료다시연호신식치계산량개기인지간적조공관계,구건적기인조공망락취득료흔호적사전솔화사준솔.병용진실적생물분자망락진행측시,실험표명,기우다시연적책략재구건기인조공망락중분연료일개중요각색.
Since a large number of models and methods of gene regulatory network(GRN)construction have been studied, the problem of data size influencing on the accuracy of the algorithm involved little. Data size influencing on the accuracy of GRN constructed by delayed information theory is studied. The experimental results show that the accuracy the GRN construc-tion can reach the steady state in a certain data size. To overcome some defects of mutual information,the mutual information value with multi-delay is introduced to calculate the regulatory relations between two genes. The constructed GRN obtained bet-ter recall ratio and precision ratio. The actual biology molecular network is tested. The experimental results verify that the multi-delay scheme plays an important role in constructing GRN.
