CAJ | 학술논문

骨髓移植是临床上治疗恶性造血系统疾病的常见手段。而铁过载是临床上常见的并发症之一，对病患的造血功能和治疗后恢复有极大的抑制作用。了解铁过载产生的分子或遗传机制能帮助优化去铁化方案，提高去铁化治疗的效率。本文总结了骨髓移植前后铁过载现象发生机制的最新研究进展，并阐述了临床上多种去铁治疗的方案，以期为该类病患铁过载的预防和治疗提供参考。
골수이식시림상상치료악성조혈계통질병적상견수단。이철과재시림상상상견적병발증지일，대병환적조혈공능화치료후회복유겁대적억제작용。료해철과재산생적분자혹유전궤제능방조우화거철화방안，제고거철화치료적효솔。본문총결료골수이식전후철과재현상발생궤제적최신연구진전，병천술료림상상다충거철치료적방안，이기위해류병환철과재적예방화치료제공삼고。
Bone marrow transplantation (BMT) is commonly used to treat hematopoietic system malignant diseases. Iron overload, which is one of the most common complications in patients undergoing BMT, has a negative impact on sur-vival after allogeneic transplantation. Better understanding of molecular mechanisms of iron overload can improve the treatment regime and improve the efficiency for iron-chelating therapy. In this review, we summarize the mechanisms of iron overload in various conditions and the progression of iron-chelating strategies in patients undergoing BMT. This review will provide insights into the prevention and treatment of patients with iron overload after BMT.