CAJ | 학술논문

目的：探讨雌激素受体（ER）、细胞原癌基因C-erbB-2和细胞周期蛋白B1（CyclinB1）在乳腺癌组织中的表达及其临床意义。方法采用免疫组化SP法检测2010~2013年接受乳腺癌根治术的70例患者乳腺癌组织中ER、C-erbB-2和CyclinB1的表达，观察其与淋巴结转移及乳腺癌病理类型、肿瘤大小、组织分级等的关系。结果乳腺癌组织中ER的表达与淋巴结转移呈负相关（r=-0.329，P<0.01），C-erbB-2、CyclinB1的表达与淋巴结转移呈正相关（r=0.467、0.548，P<0.01），CyclinB1的表达与组织分级和肿瘤大小呈显著相关（r=0.589、0.568，P<0.01）；ER和C-erbB-2的表达与病理类型、肿瘤大小、组织分级等均无相关性（P＞0.05）；CyclinB1的表达与病理类型无相关性（P＞0.05）。乳腺癌组织中ER与C-erbB-2、CyclinB1的表达呈显著负相关（r=-0.402、-0.376，P<0.01）。结论联合检测乳腺癌组织中 ER、C-erbB-2和CyclinB1的表达有助于乳腺癌预后的判断，对指导治疗和提高疗效有重要意义。
목적：탐토자격소수체（ER）、세포원암기인C-erbB-2화세포주기단백B1（CyclinB1）재유선암조직중적표체급기림상의의。방법채용면역조화SP법검측2010~2013년접수유선암근치술적70례환자유선암조직중ER、C-erbB-2화CyclinB1적표체，관찰기여림파결전이급유선암병리류형、종류대소、조직분급등적관계。결과유선암조직중ER적표체여림파결전이정부상관（r=-0.329，P<0.01），C-erbB-2、CyclinB1적표체여림파결전이정정상관（r=0.467、0.548，P<0.01），CyclinB1적표체여조직분급화종류대소정현저상관（r=0.589、0.568，P<0.01）；ER화C-erbB-2적표체여병리류형、종류대소、조직분급등균무상관성（P＞0.05）；CyclinB1적표체여병리류형무상관성（P＞0.05）。유선암조직중ER여C-erbB-2、CyclinB1적표체정현저부상관（r=-0.402、-0.376，P<0.01）。결론연합검측유선암조직중 ER、C-erbB-2화CyclinB1적표체유조우유선암예후적판단，대지도치료화제고료효유중요의의。
Objective To study the expressions of estrogen receptor(ER),C-erbB-2 and CyclinB1 in breast carcinoma tis-sues and their correlations. Methods The immunohistochemical SP method was adopted to detect the expressions of ER ,C-erB-2 and CyclinB1 in the samples of breast carcinoma tissue from 70 patients receiving breast cancer radical operation during 2010-2013. Their relation with the lymph node metastasis,breast cancer pathological types,tumor size and histological grade was ob-served. Results The ER expression in breast cancer had a negative correlation with lymph node metastasis (r=-0.329,P<0.01). The positive correlation was found between lymph node metastasis with expressions of C-erbB-2 and CyclinB1(r=0.467,0.548,P<0.01). Moreover,the CyclinB1 expression was significantly correlated with the histological type and tumor size (r=0.589,0.568,P<0.01);the expression of ER and C-erbB-2 had no correlated with the pathological types,tumor size and histological types(P>0.05);no correlation was found between the CyclinB1 expression and the pathological types (P>0.05). The ER expression had a significantly negative correlation with expressions of C-erbB-2 and CyclinB1 in breast cancer tissues(r=-0.402,-0.376,P<0.01). Conclusion The combined detection of ER,C-erbB-2 and CyclinB1 in breast cancer tissues is conducive to the judgment of breast cancer prognosis and has an important significance to guide the treatment and increase the curative effect.