中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
28期
72-74
,共3页
刘科%朱敏侠%蔡鹏%刘晓丽
劉科%硃敏俠%蔡鵬%劉曉麗
류과%주민협%채붕%류효려
HIF-1α%HIF-2α%高原藏族胃癌%表达
HIF-1α%HIF-2α%高原藏族胃癌%錶達
HIF-1α%HIF-2α%고원장족위암%표체
HIF-1α%HIF-2α%Gastric Tibetan plateau%Expression
目的 探讨HIF-1α和HIF-2α在高原藏族胃癌中的表达及其意义.方法 整群选取2013年4月—2014年4月该院收治的40例胃癌患者资料进行分析,将其设置为实验组,选择同期入院的40例非胃癌患者作为对照组,采用免疫组化SP法检测入选患者组织中的HIF-1α和HIF-2α以及VEGF表达, 分析其在高原藏族胃癌中的表达及其意义. 结果 胃癌患者HIF-1α阳性表达率62.5%,显著高于对照组(P<0.05). HIF-2α阳性表达率为37.5%,显著高于对照组(P<0.05);VEGF阳性率为65%,显著高于对照组(P<0.05).HIF-1α和淋巴结转移和TNM临床分期关系密切(P<0.05);HIF-2α和年龄、分化程度以及淋巴结转移等无相关性(P>0.05);VEGF表达和淋巴结转移、浸润深度以及临床TNM分期关系密切(P<0.05);高原藏族胃癌患者中VEGF和HIF-1α表达为正相关(P<0.05);与HIF-2α无相关性(P>0.05). 结论 HIF-1α和HIF-2α因子的表达和高原藏族胃癌的发生和发展具有紧密的联系, 治疗时加强低氧诱导因子监测, 可能对临床治疗方案具有一定的指导意义.
目的 探討HIF-1α和HIF-2α在高原藏族胃癌中的錶達及其意義.方法 整群選取2013年4月—2014年4月該院收治的40例胃癌患者資料進行分析,將其設置為實驗組,選擇同期入院的40例非胃癌患者作為對照組,採用免疫組化SP法檢測入選患者組織中的HIF-1α和HIF-2α以及VEGF錶達, 分析其在高原藏族胃癌中的錶達及其意義. 結果 胃癌患者HIF-1α暘性錶達率62.5%,顯著高于對照組(P<0.05). HIF-2α暘性錶達率為37.5%,顯著高于對照組(P<0.05);VEGF暘性率為65%,顯著高于對照組(P<0.05).HIF-1α和淋巴結轉移和TNM臨床分期關繫密切(P<0.05);HIF-2α和年齡、分化程度以及淋巴結轉移等無相關性(P>0.05);VEGF錶達和淋巴結轉移、浸潤深度以及臨床TNM分期關繫密切(P<0.05);高原藏族胃癌患者中VEGF和HIF-1α錶達為正相關(P<0.05);與HIF-2α無相關性(P>0.05). 結論 HIF-1α和HIF-2α因子的錶達和高原藏族胃癌的髮生和髮展具有緊密的聯繫, 治療時加彊低氧誘導因子鑑測, 可能對臨床治療方案具有一定的指導意義.
목적 탐토HIF-1α화HIF-2α재고원장족위암중적표체급기의의.방법 정군선취2013년4월—2014년4월해원수치적40례위암환자자료진행분석,장기설치위실험조,선택동기입원적40례비위암환자작위대조조,채용면역조화SP법검측입선환자조직중적HIF-1α화HIF-2α이급VEGF표체, 분석기재고원장족위암중적표체급기의의. 결과 위암환자HIF-1α양성표체솔62.5%,현저고우대조조(P<0.05). HIF-2α양성표체솔위37.5%,현저고우대조조(P<0.05);VEGF양성솔위65%,현저고우대조조(P<0.05).HIF-1α화림파결전이화TNM림상분기관계밀절(P<0.05);HIF-2α화년령、분화정도이급림파결전이등무상관성(P>0.05);VEGF표체화림파결전이、침윤심도이급림상TNM분기관계밀절(P<0.05);고원장족위암환자중VEGF화HIF-1α표체위정상관(P<0.05);여HIF-2α무상관성(P>0.05). 결론 HIF-1α화HIF-2α인자적표체화고원장족위암적발생화발전구유긴밀적련계, 치료시가강저양유도인자감측, 가능대림상치료방안구유일정적지도의의.
Objective To investigate the expression of HIF-1αand HIF-2α in tibetan plateau patients with gastric cancer and its significance. Methods 40 patients with gastric cancer admitted to the hospital between April 2013 and April 2014 were assigned to the observation group and other 40 people without gastric canner in the same period were assigned to the control group. The ex-pression of HIF-1α and HIF-2α and VEGF in gastric cancer tissue was determined using immunohistochemical SP method, and its significance was analyzed. Results The HIF-1α-positive rate, HIF-2α-positive rate and VEGF-positive rate were 62.5%, 37.5%, 65% respectively in the observation group, all significantly higher than those in the control group, P<0.05. There were close relationship between the expression HIF-1α and lymph node metastasis and TNM clinical stage, P<0.05; No correlation was found between the expression of HIF-2α and age, degree of differentiation and lymph node metastasis, P>0.05; there were close correlation between the expression of VEGF and lymph node metastasis, depth of invasion and clinical TNM staging, P<0.05. The expression of VEGF HIF-1αexpression was positively correlated with that of HIF-1α(P<0.05), but was not correlated with that of HIF-2α(P>0.05). Conclusion The expression of HIF-1αand HIF-2αare closely related to the occurrence and development of gastric cancer in tibetan plateau patients. Strengthening monitoring on hypoxia inducible factor may have some significance for clinical treatment.
