中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
29期
144-146
,共3页
老年初治涂阳肺结核%利福布汀%左氧氟沙星%临床效果
老年初治塗暘肺結覈%利福佈汀%左氧氟沙星%臨床效果
노년초치도양폐결핵%리복포정%좌양불사성%림상효과
Initial treatment for elderly patients with smear positive pulmonary tuberculosis%Rifabutin%Levofloxacin%Clinical effect
目的：探讨老年初治涂阳肺结核采用利福布汀和左氧氟沙星联合治疗的临床效果。方法随机选取该院2014年4月—2015年4月间符合标准的初始涂阳肺结核老年患者100例，按照随机数字表法分为治疗组和对照组，每组50例；对照组患者实施利福布汀联合吡嗪酰胺治疗，治疗组患者实施利福布汀联合左氧氟沙星治疗，观察两组患者治疗后的临床效果及不良反应情况。结果两组患者治疗后，病情均有所改善，但治疗组6个月的转阴率86.0%、9个月的转阴率96.0%显著优于对照组的46.0%和72.0%，治疗组的复发率6.0%显著低于对照组的34.0%，治疗组患者的不良反应发生率6.0%显著低于对照组的46.0%，结果具有统计学差异（P<0.05）。结论利福布汀和左氧氟沙星联合治疗老年初治涂阳肺结核，有效的提高了患者的临床转阴率，促进了临床治疗效果，降低了药物的不良反应率，减少了患者的临床痛苦，安全有效，值得临床推广。
目的：探討老年初治塗暘肺結覈採用利福佈汀和左氧氟沙星聯閤治療的臨床效果。方法隨機選取該院2014年4月—2015年4月間符閤標準的初始塗暘肺結覈老年患者100例，按照隨機數字錶法分為治療組和對照組，每組50例；對照組患者實施利福佈汀聯閤吡嗪酰胺治療，治療組患者實施利福佈汀聯閤左氧氟沙星治療，觀察兩組患者治療後的臨床效果及不良反應情況。結果兩組患者治療後，病情均有所改善，但治療組6箇月的轉陰率86.0%、9箇月的轉陰率96.0%顯著優于對照組的46.0%和72.0%，治療組的複髮率6.0%顯著低于對照組的34.0%，治療組患者的不良反應髮生率6.0%顯著低于對照組的46.0%，結果具有統計學差異（P<0.05）。結論利福佈汀和左氧氟沙星聯閤治療老年初治塗暘肺結覈，有效的提高瞭患者的臨床轉陰率，促進瞭臨床治療效果，降低瞭藥物的不良反應率，減少瞭患者的臨床痛苦，安全有效，值得臨床推廣。
목적：탐토노년초치도양폐결핵채용리복포정화좌양불사성연합치료적림상효과。방법수궤선취해원2014년4월—2015년4월간부합표준적초시도양폐결핵노년환자100례，안조수궤수자표법분위치료조화대조조，매조50례；대조조환자실시리복포정연합필진선알치료，치료조환자실시리복포정연합좌양불사성치료，관찰량조환자치료후적림상효과급불량반응정황。결과량조환자치료후，병정균유소개선，단치료조6개월적전음솔86.0%、9개월적전음솔96.0%현저우우대조조적46.0%화72.0%，치료조적복발솔6.0%현저저우대조조적34.0%，치료조환자적불량반응발생솔6.0%현저저우대조조적46.0%，결과구유통계학차이（P<0.05）。결론리복포정화좌양불사성연합치료노년초치도양폐결핵，유효적제고료환자적림상전음솔，촉진료림상치료효과，강저료약물적불량반응솔，감소료환자적림상통고，안전유효，치득림상추엄。
Objective To study the clinical effect of Rifabutin combined with Levofloxacin in the initial treatment for elderly patients with smear positive pulmonary tuberculosis. Methods 100 elderly patients with smear positive pulmonary tuberculosis in our hospital from April 2015 to April 2014 who were selected and divided into treatment group and control group according to different therapies, 50 cases each group. The control group adopted Rifabutin combined with Pyrazinamide while treatment group adopted Rifabutin combined with Levofloxacin. The clinical effect and adverse reactions of two groups was observed. Results After treatment, the symptoms of two groups were improved. The rate of turning into smear negative pulmonary tuberculosis of treatment group after 6m and 9m of treatment was 86.0% and 96.0% while the rate of control group was 46.0% and 72.0%. The recurrence rate of treatment group (6.0%) was significantly lower than that of control group (34.0%); the adverse event rate of treatment group (6.0%) was significantly lower than that of control group (46.0%) (P<0.05).Conclusion In the initial treatment for elderly patients with smear positive pulmonary tuberculosis, Rifabutin combined with Levofloxacin can effectively improve the rate of turning into smear negative pulmonary tuberculosis, promote the clinical effect, reduce the adverse event rate and reduce the clinical pains. The safe and efficient method is worthy of clinical promotion.
