山东医药
山東醫藥
산동의약
Shandong Medical Journal
2015年
41期
16-19
,共4页
脓毒症%急性肾损伤%肾功能%影响因素
膿毒癥%急性腎損傷%腎功能%影響因素
농독증%급성신손상%신공능%영향인소
sepsis%acute kidney injury%renal function%influence factors
目的 探讨脓毒症急性肾损伤( AKI)患者肾功能恢复的影响因素. 方法 选取脓毒症AKI患者193例,统计分析其性别、年龄、来源、原发感染部位、全球肾脏病预后组织( KDIGO)分期、入院24 h内急性生理与慢性健康评分系统Ⅱ( APACHE-Ⅱ)评分、住院期间机械通气、少尿/无尿、器官功能衰竭、肾替代治疗( RRT)及肾功能恢复情况.结果 193例患者中肾功能恢复110例、肾功能未恢复83例,两组年龄、KDIGO分期、APACHE-Ⅱ评分、机械通气、少尿、脏器衰竭个数、RRT比较差异均有统计学意义(P均<0.05). 经Logistic回归分析显示,患者年龄大、KDIGO分期高、APACHE-Ⅱ评分高、脏器衰竭个数多、行机械通气、少尿为影响脓毒症AKI肾功能恢复的独立危险因素(OR分别为7.676、14.404、11.542、6.137、18.235、10.333,P均<0.05),而RRT为肾功能恢复的保护性因素(OR=0.217,P<0.05). 结论 脓毒症AKI患者肾功能恢复与年龄、KDIGO分期、APACHE-Ⅱ评分、脏器衰竭个数、机械通气、少尿及RRT有关.
目的 探討膿毒癥急性腎損傷( AKI)患者腎功能恢複的影響因素. 方法 選取膿毒癥AKI患者193例,統計分析其性彆、年齡、來源、原髮感染部位、全毬腎髒病預後組織( KDIGO)分期、入院24 h內急性生理與慢性健康評分繫統Ⅱ( APACHE-Ⅱ)評分、住院期間機械通氣、少尿/無尿、器官功能衰竭、腎替代治療( RRT)及腎功能恢複情況.結果 193例患者中腎功能恢複110例、腎功能未恢複83例,兩組年齡、KDIGO分期、APACHE-Ⅱ評分、機械通氣、少尿、髒器衰竭箇數、RRT比較差異均有統計學意義(P均<0.05). 經Logistic迴歸分析顯示,患者年齡大、KDIGO分期高、APACHE-Ⅱ評分高、髒器衰竭箇數多、行機械通氣、少尿為影響膿毒癥AKI腎功能恢複的獨立危險因素(OR分彆為7.676、14.404、11.542、6.137、18.235、10.333,P均<0.05),而RRT為腎功能恢複的保護性因素(OR=0.217,P<0.05). 結論 膿毒癥AKI患者腎功能恢複與年齡、KDIGO分期、APACHE-Ⅱ評分、髒器衰竭箇數、機械通氣、少尿及RRT有關.
목적 탐토농독증급성신손상( AKI)환자신공능회복적영향인소. 방법 선취농독증AKI환자193례,통계분석기성별、년령、래원、원발감염부위、전구신장병예후조직( KDIGO)분기、입원24 h내급성생리여만성건강평분계통Ⅱ( APACHE-Ⅱ)평분、주원기간궤계통기、소뇨/무뇨、기관공능쇠갈、신체대치료( RRT)급신공능회복정황.결과 193례환자중신공능회복110례、신공능미회복83례,량조년령、KDIGO분기、APACHE-Ⅱ평분、궤계통기、소뇨、장기쇠갈개수、RRT비교차이균유통계학의의(P균<0.05). 경Logistic회귀분석현시,환자년령대、KDIGO분기고、APACHE-Ⅱ평분고、장기쇠갈개수다、행궤계통기、소뇨위영향농독증AKI신공능회복적독립위험인소(OR분별위7.676、14.404、11.542、6.137、18.235、10.333,P균<0.05),이RRT위신공능회복적보호성인소(OR=0.217,P<0.05). 결론 농독증AKI환자신공능회복여년령、KDIGO분기、APACHE-Ⅱ평분、장기쇠갈개수、궤계통기、소뇨급RRT유관.
Objective To discuss the influence factors of renal function recovery in sepsis-related acute kidney injury patients.Methods To analysis the sex, age, source, primary infection site, improving global outcomes ( KDIGO) stand-ard, acute physiology and chronic health evaluation-Ⅱ ( APACHE-Ⅱ) score in first 24 hours admitted to hospital, me-chanical ventilation, oliguria or anuria, organ functional failure, renal replacement therapy( RRT) , and renal function re-covery of 193 sepsis-related acute kidney injury patients during the hospital.Results Totally 193 cases, the recovery group of 110 cases, and non-recovery group of 83 cases.According to comparison of variables between the two groups, that age, KDIGO standard, APACHE-Ⅱscore, mechanical ventilation, oliguria, number of organ dysfunction and RRT were statistically significant ( P<0.05).Logistic regression analysis model showed that older, higher KDIGO standard, A-PACHEⅡscore, more the number of organ failure, mechanical ventilation, oliguria were the independent risk factors( OR=7.676, 14.404, 11.542, 6.137, 18.235, 10.333, all P<0.05), while the RRT was the recovery factors of renal function (OR=0.217,P<0.05).Conclusions Renal function recovery is related with many factors, such as the age, KDIGO standard, APACHE-Ⅱscore, number of organ dysfunction, mechanical ventilation, oliguria and RRT of sepsis-re-lated AKI patients.
