CAJ | 학술논문

自噬是存在于真核细胞内的一种溶酶体依赖性的降解途径，在肝脏生理和病理过程中发挥着重要作用。肝脏具有强大的再生能力，在受到急、慢性损伤时，残肝细胞将会被激活进入细胞周期进行细胞增殖，以补偿丢失的肝组织和恢复肝功能。文章阐述了各种类型损伤之后的肝再生与自噬的关系。在物理性、酒精、食源性等因素引起的肝损伤中，肝脏通过启动自噬来促进肝再生；在化学性损伤的肝再生模型中，自噬在其中的作用仍然有争议；在病毒感染之后的肝再生中，一些嗜肝病毒（如丙肝病毒和乙肝病毒等）反而利用自噬来促进病毒颗粒复制，抑制肝再生。对自噬和肝再生机制的研究，将有助于进一步阐明再生过程，为治疗肝脏疾病提供新方法。
자서시존재우진핵세포내적일충용매체의뢰성적강해도경，재간장생리화병리과정중발휘착중요작용。간장구유강대적재생능력，재수도급、만성손상시，잔간세포장회피격활진입세포주기진행세포증식，이보상주실적간조직화회복간공능。문장천술료각충류형손상지후적간재생여자서적관계。재물이성、주정、식원성등인소인기적간손상중，간장통과계동자서래촉진간재생；재화학성손상적간재생모형중，자서재기중적작용잉연유쟁의；재병독감염지후적간재생중，일사기간병독（여병간병독화을간병독등）반이이용자서래촉진병독과립복제，억제간재생。대자서화간재생궤제적연구，장유조우진일보천명재생과정，위치료간장질병제공신방법。
Autophagy is a lysosome-mediated degradation pathway, which plays an important role in hepatic physiolog-ical and pathological processes, in eukaryotic cells. The liver has a remarkable regenerative capacity. After acute or chronic injury, the residual hepatic cells can be activated to enter the cell-cycle for proliferation, in order to compensate for lost liver tissue and recover liver function. In this review, we summarize the relationship between liver regeneration (LR) after vari-ous types of injury and autophagy. For example, autophagy is activated to accelerate LR after physically, alcohol and food borne induced liver injury, while the role of autophagy in animal models of LR after chemical injury remains contro-versial. Autophagy can also be used to promote the replication of virus particles by some hepatotropic viruses (e.g., HBV, HCV) and inhibit LR after viral infection. Studies on mechanisms of autophagy and LR will contribute to clarify the regen- erative process and provide new methods for the treatment of liver disease.