遗传
遺傳
유전
Hereditas
2015年
11期
1095-1104
,共10页
lncRNA%白血病%p15%p53%miRNA
lncRNA%白血病%p15%p53%miRNA
lncRNA%백혈병%p15%p53%miRNA
lncRNA%leukemia%p15%p53%miRNA
随着分子生物学技术的飞速发展,人们对于长链非编码RNA(Long non-coding RNA,lncRNA)的研究越来越深入。lncRNA 不仅在生物体正常生物活动中不可或缺,还在许多疾病尤其是肿瘤中扮演重要角色。已有的研究表明多种lncRNA与血液系统肿瘤密切相关,具有影响抑癌基因p15表达、p53蛋白功能,以及与miRNA相互作用参与疾病等功能。本文综述了血液系统肿瘤相关的 lncRNA并着重介绍与 p15、p53、miRNA有关的lncRNA以及它们的相互作用在疾病中发挥的功能,以期能够全面了解血液系统肿瘤相关lncRNA的作用特点,为血液系统肿瘤的研究、诊断以及治疗提供新的思路。
隨著分子生物學技術的飛速髮展,人們對于長鏈非編碼RNA(Long non-coding RNA,lncRNA)的研究越來越深入。lncRNA 不僅在生物體正常生物活動中不可或缺,還在許多疾病尤其是腫瘤中扮縯重要角色。已有的研究錶明多種lncRNA與血液繫統腫瘤密切相關,具有影響抑癌基因p15錶達、p53蛋白功能,以及與miRNA相互作用參與疾病等功能。本文綜述瞭血液繫統腫瘤相關的 lncRNA併著重介紹與 p15、p53、miRNA有關的lncRNA以及它們的相互作用在疾病中髮揮的功能,以期能夠全麵瞭解血液繫統腫瘤相關lncRNA的作用特點,為血液繫統腫瘤的研究、診斷以及治療提供新的思路。
수착분자생물학기술적비속발전,인문대우장련비편마RNA(Long non-coding RNA,lncRNA)적연구월래월심입。lncRNA 불부재생물체정상생물활동중불가혹결,환재허다질병우기시종류중분연중요각색。이유적연구표명다충lncRNA여혈액계통종류밀절상관,구유영향억암기인p15표체、p53단백공능,이급여miRNA상호작용삼여질병등공능。본문종술료혈액계통종류상관적 lncRNA병착중개소여 p15、p53、miRNA유관적lncRNA이급타문적상호작용재질병중발휘적공능,이기능구전면료해혈액계통종류상관lncRNA적작용특점,위혈액계통종류적연구、진단이급치료제공신적사로。
With the rapid development of molecular biology technology, researchers have got much deeper under-standing of the role of long non-coding RNA (lncRNA). It is not only indispensable for biological processes, but also plays an important role in human diseases especially in tumor. Previous studies have shown that a variety of lncRNAs are closely associated with hematologic malignancies. These lncRNAs are involved in diseases through diverse func-tions including affecting the expression of tumor suppressor genep15, regulating p53 protein function, and interacting with miRNAs. In this review, we summarize the hematological tumor-associated lncRNAs and focus on p15, p53 and miRNA-related lncRNAs as well as the role of their interaction in hematological malignancies, which may provide a comprehensive understanding of the role of hematological tumor-associated lncRNAs and some insights for re-search, diagnosis and treatment of hematologic malignancies.