CAJ | 학술논문

目的：探讨磁敏感加权成像相位值(SWI)对于阿尔茨海默病(AD)患者脑内铁沉积的评价价值。方法随机选取AD患者30例(A组)和健康体检老年人30例(B组)，分别应用SWI检查，比较分析两组的各大脑区域内相位值及其与MMSE评分间的相关性。结果 A组各大脑区域内的相位值均显著低于B组(P<0.05)；左侧海马、双侧壳核、双侧苍白球、右侧尾状核、左侧额叶皮质以及右侧齿状核的相位值均与MMSE评分呈显著相关性(P<0.05)。结论SWI能够敏感性的反映AD患者的脑内沉积铁异常征象，对于AD的诊断与病情评估具有重要意义。
목적：탐토자민감가권성상상위치(SWI)대우아이자해묵병(AD)환자뇌내철침적적평개개치。방법수궤선취AD환자30례(A조)화건강체검노년인30례(B조)，분별응용SWI검사，비교분석량조적각대뇌구역내상위치급기여MMSE평분간적상관성。결과 A조각대뇌구역내적상위치균현저저우B조(P<0.05)；좌측해마、쌍측각핵、쌍측창백구、우측미상핵、좌측액협피질이급우측치상핵적상위치균여MMSE평분정현저상관성(P<0.05)。결론SWI능구민감성적반영AD환자적뇌내침적철이상정상，대우AD적진단여병정평고구유중요의의。
Objective To investigate the phase value of susceptibility weighted imaging (SWI) for iron deposition in the brain of Alzheimer's disease (AD) patients evaluated value. Methods AD 30 patients (A group) and 30 cases of healthy el-derly (group B), respectively, SWI inspection application, comparative analysis of the correlation between the two groups in each region of the brain phase values its relationship with MMSE scores between. Results Phase value of each brain region A group were significantly lower than in group B (P<0.05);the left hippocampus and the bilateral putamen, globus pallidus bilaterally, the right caudate nucleus, the left prefrontal cortex and the right phase values side dentate nucleus were associ-ated with MMSE scores were significantly correlated (P<0.05). Conclusion SWI can reflect the sensitivity of iron deposits in the brain of AD patients abnormal signs, for AD diagnosis and condition assessment is important.