CAJ | 학술논문

目的：探析培菲康对危重病患者胃肠功能障碍恢复的临床效果。方法随机选取该院2011年1月-2014年12月280例ICU危重病患者，将其随机分为治疗组和对照组，各为140例，治疗组在肠内营养时加用微生态制剂(培菲康)，对照组单纯给予肠内营养制剂，对比两组恢复效果。结果两组在0h时，胃肠功能评分、APACHEⅡ评分及MarshaⅡ评分比较差异无统计学意义(P>0.05)；治疗7 d后，治疗组胃肠功能评分为(0.34±0.11)分，对照组为(0.91±0.21)分；治疗组APACHEⅡ评分为(15.46±5.64)分，对照组为(19.87±6.54)分；治疗组MarshaⅡ评分为(4.23±2.33)分，对照组为(6.57±2.34)分，比较差异具有统计学意义(P<0.05)；治疗组40例发生MODS，存活35例，对照组87例发生MODS，存活35例，比较差异具有统计学意义(P<0.05)。结论微生态制剂(培菲康)对危重病患者胃肠功能障碍恢复具有显著地效果，且能够明显降低MODS的患病率及死亡率，值得应用。
목적：탐석배비강대위중병환자위장공능장애회복적림상효과。방법수궤선취해원2011년1월-2014년12월280례ICU위중병환자，장기수궤분위치료조화대조조，각위140례，치료조재장내영양시가용미생태제제(배비강)，대조조단순급여장내영양제제，대비량조회복효과。결과량조재0h시，위장공능평분、APACHEⅡ평분급MarshaⅡ평분비교차이무통계학의의(P>0.05)；치료7 d후，치료조위장공능평분위(0.34±0.11)분，대조조위(0.91±0.21)분；치료조APACHEⅡ평분위(15.46±5.64)분，대조조위(19.87±6.54)분；치료조MarshaⅡ평분위(4.23±2.33)분，대조조위(6.57±2.34)분，비교차이구유통계학의의(P<0.05)；치료조40례발생MODS，존활35례，대조조87례발생MODS，존활35례，비교차이구유통계학의의(P<0.05)。결론미생태제제(배비강)대위중병환자위장공능장애회복구유현저지효과，차능구명현강저MODS적환병솔급사망솔，치득응용。
Objective To analyze the effect of bifico in treating gastrointestinal dysfunction in critically ill patients. Methods 280 critically ill patients in ICU of our hospital from January 2011 and December 2014 were randomly divided into treatment group and control group with 140 in each one. The treatment group was treated with enteral nutrition support and micro-e-cological preparation (Bifico), while the control group was simply treated with microbial ecological agents. The outcomes were compared between the two groups. Results At the beginning, no statistically significant difference can be found in gas-trointestinal function score, APACHE II score, APACHE IIscore between the two groups, P>0.05; 7 days after treatment, the APACHE II score was(15.46±5.64)in the treatment group and(19.87±6.54)in the control group, and the APACHEIIscore was (4.23±2.33) in the treatment group and (6.57±2.34) in the control group, and the differences above were both statistically significant, P<0.05;MODS was found in 40 patients in the treatment group with 35 surviving, and in 87 patients in the control group with 35 surviving, and the difference between the two groups was statistically significant, P<0.05). Conclusion Micro-ecological preparation (Bifico) has remarkable effect in treating gastrointestinal dysfunction in critically ill patients, what's more, it can significantly reduce the MODS morbidity and mortality and is worthy of application.