CAJ | 학술논문

目的：对比分析米氮平与重复经颅磁刺激(rTMS)对脑卒中后抑郁的临床疗效。方法整群选择该院精神科2014年2月-2015年2月收治的76例脑卒中后抑郁患者，按照随机数字表将其分为治疗组及对照组，各38例。两组均接受常规脑卒中治疗，对照组应用米氮平，治疗组应用rTMS(刺激部位右额叶背外侧，80%运动阈值，1Hz，40脉冲，30串，间隔2s，5次/周，共接受6周治疗)，比较两组治疗后第6周的汉密顿抑郁量表(HAMD)评分及不良反应。结果治疗后治疗组抑郁评分为(13.12±3.20)分，明显低于对照组(15.52±3.15)分，(P<0.01)；治疗组不良反应发生率为5.26%，明显低于对照组42.11%(P<0.01)。结论采用rTMS治疗脑卒中后抑郁有助于缓解患者抑郁情绪、减低不良反应发生率。
목적：대비분석미담평여중복경로자자격(rTMS)대뇌졸중후억욱적림상료효。방법정군선택해원정신과2014년2월-2015년2월수치적76례뇌졸중후억욱환자，안조수궤수자표장기분위치료조급대조조，각38례。량조균접수상규뇌졸중치료，대조조응용미담평，치료조응용rTMS(자격부위우액협배외측，80%운동역치，1Hz，40맥충，30천，간격2s，5차/주，공접수6주치료)，비교량조치료후제6주적한밀돈억욱량표(HAMD)평분급불량반응。결과치료후치료조억욱평분위(13.12±3.20)분，명현저우대조조(15.52±3.15)분，(P<0.01)；치료조불량반응발생솔위5.26%，명현저우대조조42.11%(P<0.01)。결론채용rTMS치료뇌졸중후억욱유조우완해환자억욱정서、감저불량반응발생솔。
Objective To compare the effect of mirtazapine with repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients with depression after stroke. Methods 76 patients with depression after stroke admitted to the psychi-atric department in our hospital from February 2014 and February 2015 were included and divided into treatment group and control group according to random number table with 38 in each one. All the patients received conventional treatment for cerebral apoplexy. Mirtazapine was used in the control group, while rTMS (exciting place right frontal dorsolateral, 80%threshold, 1 Hz, 40 pulse, 30 series, interval of 2 s, 5 times per week, a total of 6 weeks treatment) was used in the treat-ment group. The HAMD score 6 weeks after treatment and the adverse reaction of the two groups were compared between the two groups. Results After treatment, the HAMD score (13.12±3.20 vs 15.52±3.15) was significantly lower in the treat-ment group than in the control group, P<0.01; the adverse reaction rate (5.26% vs 42.11%) was significantly lower in the treatment group than in the control group, P<0.01. Conclusion rTMS in the treatment of patients with depression after stroke is conducive to relieving depression and lowering the adverse reaction rate.