CAJ | 학술논문

目的:探讨由良性透明细胞腺纤维瘤不典型增生、癌变发展而来的透明细胞癌的临床病理特征.方法:运用HE、免疫组化及特殊染色等对2例良性、交界性腺纤维瘤及腺纤维瘤型透明细胞癌并存的卵巢肿瘤行进行观察,并结合文献进行分析.结果:肿瘤呈囊实性、蜂窝状,可见良性的腺纤维瘤区域,部分腺上皮出现不典型性表现为交界性腺纤维瘤,灶性癌变移行为透明细胞癌;免疫组化 AE1/AE3、CAM5.2、EMA、PAX8、CA125、P53 阳性,ER、PR、WT1阴性;PAS染色透明细胞胞浆及管腔内黏液阳性.结论:卵巢腺纤维瘤型透明细胞癌起源于腺纤维瘤,与子宫内膜异位型透明细胞癌在起源、分子生物学改变及生物学行为存在一定异同,早期病例预后好.
목적:탐토유량성투명세포선섬유류불전형증생、암변발전이래적투명세포암적림상병리특정.방법:운용HE、면역조화급특수염색등대2례량성、교계성선섬유류급선섬유류형투명세포암병존적란소종류행진행관찰,병결합문헌진행분석.결과:종류정낭실성、봉와상,가견량성적선섬유류구역,부분선상피출현불전형성표현위교계성선섬유류,조성암변이행위투명세포암;면역조화 AE1/AE3、CAM5.2、EMA、PAX8、CA125、P53 양성,ER、PR、WT1음성;PAS염색투명세포포장급관강내점액양성.결론:란소선섬유류형투명세포암기원우선섬유류,여자궁내막이위형투명세포암재기원、분자생물학개변급생물학행위존재일정이동,조기병례예후호.
Objective:To investigate the clinical pathological features of clear cell carcinoma developed by benign clear cell adenofibroma for atypical hyperplasia and canceration.Methods:We observed 2 cases of ovarian tumors with benign,borderline adenofibroma complicated with adenocarcinoma type clear cell carcinoma,and analyzed it combining literature.Results:The tumor was cystic and honeycomb,there was benign adenofibroma area,part of glandular epithelium was not typical as the borderline adenofibroma,it changed into clear cell carcinoma by focal canceration.In immunohistochemistry,AE1/AE3,CAM5.2,EMA,PAX8, CA125,P53 were positive,ER,PR,WT1 were negative.In PAS staining,the cytoplasm of the clear cell and the mucus in the lumen were positive.Conclusion:Ovarian adenocarcinoma type clear cell carcinoma was originated from the adenocarcinoma,it had some similarities and differences in the origin,molecular biology and biological behavior with endometriosis type clear cell carcinoma, the prognosis of early cases was good.