CAJ | 학술논문

目的观察新辅助化疗措施在局部晚期宫颈癌患者治疗中的临床效果,并分析其毒性反应. 方法将该院2013年12月至2014年12月确诊收治的56例局部晚期宫颈癌患者分为对照组和观察组,各28例.对照组患者采取常规化疗(顺铂)方法,观察组患者给予联合辅助化疗(顺铂+伊立替康)措施治疗.结果观察组治疗后,总缓解率达57.1%(16/28),显著高于对照组的35.7%(10/28),差异有统计学意义(P<0.05).观察组患者恶心呕吐、脱发发生率均显著低于对照组,差异有统计学意义(P<0.05).观察组患者治疗后肿瘤直径较对照组显著缩小,差异有统计学意义(P<0.05).结论在局部晚期宫颈癌患者的治疗中,新辅助化疗的临床效果显著,且毒性反应小.
목적 관찰신보조화료조시재국부만기궁경암환자치료중적림상효과,병분석기독성반응. 방법장해원2013년12월지2014년12월학진수치적56례국부만기궁경암환자분위대조조화관찰조,각28례.대조조환자채취상규화료(순박)방법,관찰조환자급여연합보조화료(순박+이립체강)조시치료.결과 관찰조치료후,총완해솔체57.1%(16/28),현저고우대조조적35.7%(10/28),차이유통계학의의(P<0.05).관찰조환자악심구토、탈발발생솔균현저저우대조조,차이유통계학의의(P<0.05).관찰조환자치료후종류직경교대조조현저축소,차이유통계학의의(P<0.05).결론 재국부만기궁경암환자적치료중,신보조화료적림상효과현저,차독성반응소.
Objective To observe the effect of neoadjuvant chemotherapeutic measures in the patients with locally ad-vanced cervical cancer and to analyze its toxic reactions. Methods 56 cases of locally advanced cervical cancer in our hospital from December 2013 to December 2014 were divided into the control group and the observation group ,28 cases in each group. The control group adopted the routine chemotherapy ,while the observation group was given the adjuvant chemotherapeutic mea-sures. Results The overall remission rate after chemotherapy in the observation group was 57.1%(16/28),which was signifi-cantly higher than 35.7%(10/28) in the control group,the difference was statistically significant(P<0.05). The occurrence rates of nausea,vomiting and alopecia in the observation group were significantly lower than those in the control group with statistical dif-ference(P<0.05). In addition,the tumor diameter after treatment in the observation group was significantly decreased compared with the control group,the difference was statistically significant(P<0.05). Conclusion The neoadjuvant chemotherapy for treat-ing locally advanced cervical cancer has significantly clinical effect and small toxic reactions.