CAJ | 학술논문

目的观察乌苯美司联合小剂量阿糖胞苷治疗老年急性髓系白血病的疗效.方法将该院2010年9月至2014年10月收治的47例(不含M3型)老年急性髓系白血病患者分为两组,治疗组25例采用乌苯美司联合小剂量阿糖胞苷诱导治疗;对照组22例单独给予小剂量阿糖胞苷治疗.结果治疗组患者中完全缓解4例,部分缓解15例;对照组患者中完全缓解1例,部分缓解7例;治疗组患者治疗反应率[76.0%(19/25)]高于对照组[36.4%(8/22)],差异有统计学意义(P<0.05).化疗后治疗组T细胞(CD3+)、辅助诱导T细胞(CD3+、CD4+)及NK细胞(CD16+、CD56+)数均高于对照组,差异有统计学意义(P<0.05).治疗组患者感染、出血、心脏毒性不良反应发生率均低于对照组,差异有统计学意义(P<0.05).根据卡氏评分,治疗组患者化疗后体能状态优于对照组,差异有统计学意义(P<0.05).结论乌苯美司联合小剂量阿糖胞苷对老年急性髓系白血病的诱导治疗反应率较高,能改善患者细胞免疫功能,降低化疗相关不良反应,使老年患者更能耐受化疗,提高其生活质量.
목적 관찰오분미사연합소제량아당포감치료노년급성수계백혈병적료효.방법 장해원2010년9월지2014년10월수치적47례(불함M3형)노년급성수계백혈병환자분위량조,치료조25례채용오분미사연합소제량아당포감유도치료;대조조22례단독급여소제량아당포감치료.결과 치료조환자중완전완해4례,부분완해15례;대조조환자중완전완해1례,부분완해7례;치료조환자치료반응솔[76.0%(19/25)]고우대조조[36.4%(8/22)],차이유통계학의의(P<0.05).화료후치료조T세포(CD3+)、보조유도T세포(CD3+、CD4+)급NK세포(CD16+、CD56+)수균고우대조조,차이유통계학의의(P<0.05).치료조환자감염、출혈、심장독성불량반응발생솔균저우대조조,차이유통계학의의(P<0.05).근거잡씨평분,치료조환자화료후체능상태우우대조조,차이유통계학의의(P<0.05).결론 오분미사연합소제량아당포감대노년급성수계백혈병적유도치료반응솔교고,능개선환자세포면역공능,강저화료상관불량반응,사노년환자경능내수화료,제고기생활질량.
Objective To observe the clinical efficacy of ubenimex combined with small dose of cytarabine in the treat-ment of senile acute myeloid leukemia(AML). Methods 47 cases of senile AML(not containing M3 subtype) in this hospital from September 2010 to October 2014 were divided into two groups. The treatment group (25 cases) adopted ubenimex combined with small dose of cytarabine induction therapy,while the control group(22 cases) was given small dose of cytarabine alone. Results In the treatment group,there were 4 cases of complete remission(CR) and 15 cases of partial remission(PR);while in the control group, there were 1 case of CR and 7 cases of PR;the response rate in the treatment group was 76.0%(19/25),which was higher than 36.4%(8/22) in the control group,the difference was statistically significant(P<0.05). T lymphocytes(CD3+),T assisted in-duced lymphocytes(CD3+,CD4+) and NK cells(CD16+,CD56+) after chemotherapy in the treatment group were higher than those in the control group,the differences were statistically significant(P<0.05);the occurrence rate of adverse reactions such as infection, hemorrhage and cardiac toxicity in the treatment group was lower than that in the control group (P<0.05);according to the Kamof-sky score,the performance status after chemotherapy in the treatment group was better than that in the control group ,the differ-ence was statistically significant(P<0.05). Conclusion Ubenimex combined with small dose of cytarabine in the induction treat-ment of senile AML patients has higher response rate,can improve the cellular immune function,decreases the chemotherapeutic related adverse reactions,makes the elderly patients to tolerate the chemotherapy and improves the life quality.