CAJ | 학술논문

microRNAs(miRNAs)是近年发现的一种高度保守的非编码小RNA,它们通过抑制靶基因mRNA的翻译或将其降解,在转录后水平调控基因的表达,参与调控哺乳动物多个器官的发育过程和人类疾病的发生.miR-17-92基因簇是一个高度保守的基因簇,编码miR-17-5p、miR-17-3p、miR-18a、miR-19a、miR-20a、miR-19b-1和miR-92-1等7个miRNAs.大量证据表明,miR-17-92基因簇miRNAs参与了心、肺、免疫系统的发育、血管生长及前脂肪细胞的分化等过程.此外,miR-17-92基因簇miRNAs在多种肿瘤中高表达,能作为致癌基因诱发淋巴瘤和血管化肿瘤的发生,但它也可以作为抑癌基因抑制乳腺癌细胞的增殖.文章对miR-17-92基因簇miRNAs在哺乳动物器官发育及肿瘤发生中的作用进行综述.
microRNAs(miRNAs)시근년발현적일충고도보수적비편마소RNA,타문통과억제파기인mRNA적번역혹장기강해,재전록후수평조공기인적표체,삼여조공포유동물다개기관적발육과정화인류질병적발생.miR-17-92기인족시일개고도보수적기인족,편마miR-17-5p、miR-17-3p、miR-18a、miR-19a、miR-20a、miR-19b-1화miR-92-1등7개miRNAs.대량증거표명,miR-17-92기인족miRNAs삼여료심、폐、면역계통적발육、혈관생장급전지방세포적분화등과정.차외,miR-17-92기인족miRNAs재다충종류중고표체,능작위치암기인유발림파류화혈관화종류적발생,단타야가이작위억암기인억제유선암세포적증식.문장대miR-17-92기인족miRNAs재포유동물기관발육급종류발생중적작용진행종술.
MicroRNAs (miRNAs) are a new class of small, non-coding RNAs that regulate gene expression. The base pairing interactions between miRNAs and their target mRNAs, often within the 3'-untranslated region (UTR) of target genes, result in the degradation of target mRNAs or repression of their translation. MiRNAs regulate a diverse range of physiological processes, including cell differentiation and proliferation, mammalian development and human disease. Many studies have shown that miR-17-92 cluster, which encodes miR-17-5p, miR-17-3p, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92-1, is expressed in many mammalian tissues. This cluster contributes to the development of heart, lung, blood vessel, and immune system. In addition, it can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene. However, miR-17-92 cluster proved to suppress breast cancer cell proliferation and tumor colony formation as a tumor suppressor. This paper reviews the roles of miR-17-92 cluster in mammal development and the relationship between miR-17-92 cluster and tumorigenesis.