现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
MODERN JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2009年
24期
2899-2901
,共3页
姜黄胶囊%糖尿病足%大鼠
薑黃膠囊%糖尿病足%大鼠
강황효낭%당뇨병족%대서
turmeric capsule%diabetic foot%rat
目的 观察姜黄胶囊(CC)对糖尿病足(DF)大鼠模型空腹血糖(FBG)、空腹血清胰岛素(FSI)、血流变(CBF)及足部溃疡症状的影响.方法 选用SPF级健康雄性Wistar大鼠 60只,随机抽取10只作为正常对照组,其余50只制作糖尿病足模型,47只造模成功,按随机数字表法分为姜黄胶囊高剂量治疗组(CH组,16只)、中剂量治疗组(CM组,11只)、低剂量治疗组(CL组,10只)和糖尿病足空白对照组(DFB组, 10只);正常对照组大鼠仅建立足溃疡模型.造模后对各组大鼠进行药物干预,于腹主动脉采血,测定FBG、FSI、CBF.结果 CH、CM组FBG水平较CL组明显降低(P均＜0.05);CH、CM组FSI较CL组明显升高(P均＜0.05);血流变中低切变率、血浆黏度、红细胞压积、红细胞聚集指数及红细胞变形指数CH、CM组与CL组比较存在显著性差异(P均＜0.05);3组治疗后的体质量、血流变中的高切变率及足部症状评分比较均无显著性差异(P＞0.05).结论 姜黄胶囊对糖尿病足大鼠具有较好的降低血糖、升高空腹血清胰岛素、改善糖尿病足大鼠的血流变和局部血液循环的作用,姜黄胶囊治疗糖尿病足的作用机制与姜黄胶囊降低血糖、改善血液流变学情况有关.
目的 觀察薑黃膠囊(CC)對糖尿病足(DF)大鼠模型空腹血糖(FBG)、空腹血清胰島素(FSI)、血流變(CBF)及足部潰瘍癥狀的影響.方法 選用SPF級健康雄性Wistar大鼠 60隻,隨機抽取10隻作為正常對照組,其餘50隻製作糖尿病足模型,47隻造模成功,按隨機數字錶法分為薑黃膠囊高劑量治療組(CH組,16隻)、中劑量治療組(CM組,11隻)、低劑量治療組(CL組,10隻)和糖尿病足空白對照組(DFB組, 10隻);正常對照組大鼠僅建立足潰瘍模型.造模後對各組大鼠進行藥物榦預,于腹主動脈採血,測定FBG、FSI、CBF.結果 CH、CM組FBG水平較CL組明顯降低(P均＜0.05);CH、CM組FSI較CL組明顯升高(P均＜0.05);血流變中低切變率、血漿黏度、紅細胞壓積、紅細胞聚集指數及紅細胞變形指數CH、CM組與CL組比較存在顯著性差異(P均＜0.05);3組治療後的體質量、血流變中的高切變率及足部癥狀評分比較均無顯著性差異(P＞0.05).結論 薑黃膠囊對糖尿病足大鼠具有較好的降低血糖、升高空腹血清胰島素、改善糖尿病足大鼠的血流變和跼部血液循環的作用,薑黃膠囊治療糖尿病足的作用機製與薑黃膠囊降低血糖、改善血液流變學情況有關.
목적 관찰강황효낭(CC)대당뇨병족(DF)대서모형공복혈당(FBG)、공복혈청이도소(FSI)、혈류변(CBF)급족부궤양증상적영향.방법 선용SPF급건강웅성Wistar대서 60지,수궤추취10지작위정상대조조,기여50지제작당뇨병족모형,47지조모성공,안수궤수자표법분위강황효낭고제량치료조(CH조,16지)、중제량치료조(CM조,11지)、저제량치료조(CL조,10지)화당뇨병족공백대조조(DFB조, 10지);정상대조조대서부건립족궤양모형.조모후대각조대서진행약물간예,우복주동맥채혈,측정FBG、FSI、CBF.결과 CH、CM조FBG수평교CL조명현강저(P균＜0.05);CH、CM조FSI교CL조명현승고(P균＜0.05);혈류변중저절변솔、혈장점도、홍세포압적、홍세포취집지수급홍세포변형지수CH、CM조여CL조비교존재현저성차이(P균＜0.05);3조치료후적체질량、혈류변중적고절변솔급족부증상평분비교균무현저성차이(P＞0.05).결론 강황효낭대당뇨병족대서구유교호적강저혈당、승고공복혈청이도소、개선당뇨병족대서적혈류변화국부혈액순배적작용,강황효낭치료당뇨병족적작용궤제여강황효낭강저혈당、개선혈액류변학정황유관.
Objective It is to observe the influence of turmeric capsule (CC) on fasting blood glucose (FBG), fasting serum insulin (FSI), blood flow changes (CBF) and the impact of foot ulcer symptoms of rats with diabetic foot (DF). Methods 60 SPF-class healthy male Wistar rats were selected, and randomly selected 10 cases as normal control group, and 47 of the remaining 50 rats were made DF model successfully, and randomly divided into CC high-dose group (CHG, 16 rats), middle-doses group (CMG, 11 rats), low-dose group (CLG, 10 rats) and DF blank control group (DFBG, 10 rats); the foot ulcers were made only in normal control group. The drug intervention was executed, then the blood was collected from the abdominal aorta to measure FBG, FSI, CBF. Results The levels of FBG in CHG and CMG was significantly lower than CLG (P＜0.05); and the levels of FSI in CHG and CMG was significantly higher than CLG (P＜0.05); there is significant difference in blood flow change in the low shear rate, plasma viscosity, hematocrit, erythrocyte aggregation index and RBC deformability index of in CHG and CMG compared with CLG (P＜0.05). There was no significant difference in the body weight, blood flow changes and foot symptom score in the high shear rate among three groups after treatment(P＞0.05). Conclusion CC has better action to lower FBG, elevated FSI and improves blood flow in rats with DF and change the role of local blood circulation. The mechanism of CC in the treatment of DF is in a relationship with the situation of lower blood sugar and improves hemorrheology.
