华西药学杂志
華西藥學雜誌
화서약학잡지
WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
2000年
5期
371-372
,共2页
质子泵抑制剂%药物相互作用%肝药酶%细胞色素P450
質子泵抑製劑%藥物相互作用%肝藥酶%細胞色素P450
질자빙억제제%약물상호작용%간약매%세포색소P450
Proton pump inhibitor%Drug interaction%Microsomes%P450
质子泵抑制剂奥美拉唑、兰索拉唑和盘托拉唑主要经细胞色素P450(CYP)的异构酶CYP2C19代谢消除。研究表明，三个质子泵抑制剂对其它经CYP系列代谢的药物皆表现出较弱的相互作用，少数文献报道这一相互作用无临床相关性，并且未发现剂量与不良反应的相关性。预示了该类药物临床使用或合用的安全性。
質子泵抑製劑奧美拉唑、蘭索拉唑和盤託拉唑主要經細胞色素P450(CYP)的異構酶CYP2C19代謝消除。研究錶明，三箇質子泵抑製劑對其它經CYP繫列代謝的藥物皆錶現齣較弱的相互作用，少數文獻報道這一相互作用無臨床相關性，併且未髮現劑量與不良反應的相關性。預示瞭該類藥物臨床使用或閤用的安全性。
질자빙억제제오미랍서、란색랍서화반탁랍서주요경세포색소P450(CYP)적이구매CYP2C19대사소제。연구표명，삼개질자빙억제제대기타경CYP계렬대사적약물개표현출교약적상호작용，소수문헌보도저일상호작용무림상상관성，병차미발현제량여불량반응적상관성。예시료해류약물림상사용혹합용적안전성。
Proton pump inhibitors were metabolized with the sub-enzyme CYP2C19 of microsomes P450.The study shows that three of PPI were weak interaction with other drugs when CYP enzyme effected.Some of the research pressed that there were not relative in clinic,also there were no relative with dose and side effect.Result is infered that PPI is the safe drug both using and combining in clinic.
