分析化学
分析化學
분석화학
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
2009年
11期
1566-1571
,共6页
杨庆德%刘红敏%刘春秀%贺银增%田青%蔡新霞
楊慶德%劉紅敏%劉春秀%賀銀增%田青%蔡新霞
양경덕%류홍민%류춘수%하은증%전청%채신하
透皮取样技术%葡萄糖传感器%有限空间%电极损耗%电极掩膜
透皮取樣技術%葡萄糖傳感器%有限空間%電極損耗%電極掩膜
투피취양기술%포도당전감기%유한공간%전겁손모%전겁엄막
Transdermal sampling techniques%glucose sensor%finite space%electrode loss%electrode mask
本研究分析并解决了在透皮无创血糖监测技术中的几个关键电化学问题.针对葡萄糖传感器的线性范围,提出使用新的校正方程标定葡萄糖传感器,使得传感器的线性范围增加到原来的20倍以上.针对透皮无创血糖监测中特有的"有限空间",建立了新的扩散模型进行分析,确立了适于无创血糖检测的采样时刻.针对传感器长时间血糖监测中电极损耗,提出"电极掩膜"的概念,避免了传感器电极的失效.在解决以上关键问题后,得出了较好的动物实验数据.以有创检测值为对照,97个无创血糖值中,70.10%的数据属临床准确,29.90%的数据为临床相对准确.本研究为透皮无创血糖监测技术的实现和优化奠定了基础.
本研究分析併解決瞭在透皮無創血糖鑑測技術中的幾箇關鍵電化學問題.針對葡萄糖傳感器的線性範圍,提齣使用新的校正方程標定葡萄糖傳感器,使得傳感器的線性範圍增加到原來的20倍以上.針對透皮無創血糖鑑測中特有的"有限空間",建立瞭新的擴散模型進行分析,確立瞭適于無創血糖檢測的採樣時刻.針對傳感器長時間血糖鑑測中電極損耗,提齣"電極掩膜"的概唸,避免瞭傳感器電極的失效.在解決以上關鍵問題後,得齣瞭較好的動物實驗數據.以有創檢測值為對照,97箇無創血糖值中,70.10%的數據屬臨床準確,29.90%的數據為臨床相對準確.本研究為透皮無創血糖鑑測技術的實現和優化奠定瞭基礎.
본연구분석병해결료재투피무창혈당감측기술중적궤개관건전화학문제.침대포도당전감기적선성범위,제출사용신적교정방정표정포도당전감기,사득전감기적선성범위증가도원래적20배이상.침대투피무창혈당감측중특유적"유한공간",건립료신적확산모형진행분석,학립료괄우무창혈당검측적채양시각.침대전감기장시간혈당감측중전겁손모,제출"전겁엄막"적개념,피면료전감기전겁적실효.재해결이상관건문제후,득출료교호적동물실험수거.이유창검측치위대조,97개무창혈당치중,70.10%적수거속림상준학,29.90%적수거위림상상대준학.본연구위투피무창혈당감측기술적실현화우화전정료기출.
Several key problems were analysed for the transdermal noninvasive glucose monitoring. A modified calibration equation was proposed for the high-sensitivity glucose biosensor due to its narrow linear range. The new equation has increased the sensors' linear range by 20 times. A new diffuse model was constructed for the electrode system of glucose sensor,aiming at the unique "finite space" electrochemical problem in trans-dermal technique. In addition,electrode masks were utilized to solve the problem of electrode loss in longtime glucose monitoring. In animal in-vivo experiments,70.1 % of the noninvasive glucose data points were clinically accurate,while the remains were clinically acceptable. All solutions mentioned above were based on both theoretical analysis and experimental validation,promoting the realization and optimization of transdermal noninvasive glucose monitoring techniques.