CAJ | 학술논문

目的：探讨大鼠切除松果体后对海洛因依赖性的改变。方法：首先对大鼠实施松果体切除手术，切除松果体大鼠、手术对照组大鼠以及正常大鼠通过剂量递增法0.5～8.0 mg*d-1*kg-1建立海洛因依赖模型。然后腹腔注射纳洛酮进行催促戒断。结果：大鼠切除松果体后的部分戒断症状，如异常动作、咬牙、腹泻及体重变化等均高于手术对照组及正常组大鼠，总戒断评分之间也有显著性差异。结论：提示松果体可能通过分泌褪黑素以及其它方式在海洛因依赖中起一定作用。
목적：탐토대서절제송과체후대해락인의뢰성적개변。방법：수선대대서실시송과체절제수술，절제송과체대서、수술대조조대서이급정상대서통과제량체증법0.5～8.0 mg*d-1*kg-1건립해락인의뢰모형。연후복강주사납락동진행최촉계단。결과：대서절제송과체후적부분계단증상，여이상동작、교아、복사급체중변화등균고우수술대조조급정상조대서，총계단평분지간야유현저성차이。결론：제시송과체가능통과분비퇴흑소이급기타방식재해락인의뢰중기일정작용。
OBJECTIVE:To investigate the effect of pineal on heroin dependent.METHODS：First,pinealectomy was performed;Second,pinealectomy rats,false pinealectomy rats and normal rats were given heroin ［from 0.5 mg*(kg*d)-1 to 8.0 mg*(kg*d)-1 for 22 days］ to form the heroin-dependent models.All rats were injected naloxone to precipitate withdrawal after stopping injection heroin for 16 hours.RESULTS:Partial withdrawal syndrome score of pinealectomy group as abnormal motion,chatterling and general score were higher compared with that of false pinealectomy group(P<0.01,P<0.01,P<0.05).CONCLUTION:This study suggested that pineal had some affection on heroin-dependent rats.Its principle might be to secreting melatonin or other ways.