中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2009年
18期
15-16
,共2页
抑郁症%艾司西酞普兰%阿米替林
抑鬱癥%艾司西酞普蘭%阿米替林
억욱증%애사서태보란%아미체림
Depression%Escitalopram%Amitriptylline
目的 探讨艾司西酞普兰治疗抑郁症的疗效及安全性.方法 将68例抑郁症患者随机入组, 分为艾司西酞普兰组和阿米替林组,艾司西酞普兰组治疗剂量10～20 mg/d,阿米替林组治疗剂量100～300 mg/d,采用HAMD、TESS量表,在用药前及用药后1、2、4、6周末评定比较. 结果艾司西酞普兰组和阿米替林组疗效相当,无显著性差异( P >0.05),但艾司西酞普兰起效更快,不良反应更少,不良反应艾司西酞普兰以食欲减退、恶心、呕吐为主,阿米替林以口干、便秘、视物模糊、排尿困难、头昏、无力及心电图异常为主.结论 艾司西酞普兰治疗抑郁症安全有效.
目的 探討艾司西酞普蘭治療抑鬱癥的療效及安全性.方法 將68例抑鬱癥患者隨機入組, 分為艾司西酞普蘭組和阿米替林組,艾司西酞普蘭組治療劑量10～20 mg/d,阿米替林組治療劑量100～300 mg/d,採用HAMD、TESS量錶,在用藥前及用藥後1、2、4、6週末評定比較. 結果艾司西酞普蘭組和阿米替林組療效相噹,無顯著性差異( P >0.05),但艾司西酞普蘭起效更快,不良反應更少,不良反應艾司西酞普蘭以食欲減退、噁心、嘔吐為主,阿米替林以口榦、便祕、視物模糊、排尿睏難、頭昏、無力及心電圖異常為主.結論 艾司西酞普蘭治療抑鬱癥安全有效.
목적 탐토애사서태보란치료억욱증적료효급안전성.방법 장68례억욱증환자수궤입조, 분위애사서태보란조화아미체림조,애사서태보란조치료제량10～20 mg/d,아미체림조치료제량100～300 mg/d,채용HAMD、TESS량표,재용약전급용약후1、2、4、6주말평정비교. 결과애사서태보란조화아미체림조료효상당,무현저성차이( P >0.05),단애사서태보란기효경쾌,불량반응경소,불량반응애사서태보란이식욕감퇴、악심、구토위주,아미체림이구간、편비、시물모호、배뇨곤난、두혼、무력급심전도이상위주.결론 애사서태보란치료억욱증안전유효.
Objective:To detect the efficacy and side effects of escitalopram in the treatment of depression. Methods:68 patients with major depression were divided randomly into two groups:escitalopram group and amitriptyline group. The does of amitriptyline group were 100～300mg/d, the does of escitalopram group were 20～60 mg/d. HAMD, TESS were evaluated before treatment and at the end of 1、2,4,6 weeks after treatment.Results: The effects of escitalopram group and amitriptyline group were no significant difference (P>0.05). Escitalopram took effect more quickly and less side effects than amitriptyline .The side effects of escitalopram group were loss appetite ,nausea, vomiting and those of amitriptyline group were dry mouth, constipation, blurred vision, difficult urination, dizziness, lack strength and ECG abnormality.Conclusions: escitalopram is a safe and effective antidepressant.
