中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2009年
21期
36-38
,共3页
茶皂素%局灶性脑缺血%自由基%一氧化氮
茶皂素%跼竈性腦缺血%自由基%一氧化氮
다조소%국조성뇌결혈%자유기%일양화담
Tea saponin Focal cerebral ischemia Free radicals Nitric oxide
目的 观察茶皂素对大鼠局灶性脑缺血再灌注损伤的保护作用.方法 采用线栓法制备大鼠局灶性脑缺血再灌注模型,以茶皂素灌胃给药.观测其对脑缺血大鼠的神经行为、脑组织超氧化物歧化酶(SOD)、一氧化氮合酶(NOS)活性及一氧化氮(NO)、活性氧(ROS)、丙二醛(MDA)含量的影响.结果 茶皂素能明显改善脑缺血大鼠的神经行为.拮抗脑缺血再灌注引起的SOD活力的下降及ROS、MDA含量的升高,并使脑缺血大鼠的脑组织中NO及NOS水平明显下降.结论 茶皂素对大鼠局灶性脑缺血再灌注损伤具有很好的保护作用.
目的 觀察茶皂素對大鼠跼竈性腦缺血再灌註損傷的保護作用.方法 採用線栓法製備大鼠跼竈性腦缺血再灌註模型,以茶皂素灌胃給藥.觀測其對腦缺血大鼠的神經行為、腦組織超氧化物歧化酶(SOD)、一氧化氮閤酶(NOS)活性及一氧化氮(NO)、活性氧(ROS)、丙二醛(MDA)含量的影響.結果 茶皂素能明顯改善腦缺血大鼠的神經行為.拮抗腦缺血再灌註引起的SOD活力的下降及ROS、MDA含量的升高,併使腦缺血大鼠的腦組織中NO及NOS水平明顯下降.結論 茶皂素對大鼠跼竈性腦缺血再灌註損傷具有很好的保護作用.
목적 관찰다조소대대서국조성뇌결혈재관주손상적보호작용.방법 채용선전법제비대서국조성뇌결혈재관주모형,이다조소관위급약.관측기대뇌결혈대서적신경행위、뇌조직초양화물기화매(SOD)、일양화담합매(NOS)활성급일양화담(NO)、활성양(ROS)、병이철(MDA)함량적영향.결과 다조소능명현개선뇌결혈대서적신경행위.길항뇌결혈재관주인기적SOD활력적하강급ROS、MDA함량적승고,병사뇌결혈대서적뇌조직중NO급NOS수평명현하강.결론 다조소대대서국조성뇌결혈재관주손상구유흔호적보호작용.
Objective:To observe the protective effect of tea saponin on Focal cerebral ischemia-reperfusion injury.Methods: Make focal cerebral ischemia-reperfusion model of rat by suture, delivery tea saponin by Ig.To observe the influence of tea saponin to neurobehavioral and brain superoxide dismutase (SOD), nitric oxide synthase (NOS) activity and nitric oxide (NO), reactive oxygen species (ROS), malondialdehyde (MDA) content in cerebral ischemia rats. Results:Tea saponin can improve neurobehavioral in cerebral ischemia rats obvious -ly and antagonist cerebral iscbemia-reperfusion-induced decline in SOD vitality and ROS, MDA content increased and make the levels of NO and NOS decreased obviously in brain tissue of cerebral ischemia rat.Conclusion:Tea saponin can protect the rats with focal cerebral ischemia-reperfusion injury very well.
