华西药学杂志
華西藥學雜誌
화서약학잡지
WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
2000年
5期
331-334
,共4页
甾体%甾体甲基转移酶%甾体生物合成抑制剂%甾体甲基化酶抑制剂
甾體%甾體甲基轉移酶%甾體生物閤成抑製劑%甾體甲基化酶抑製劑
치체%치체갑기전이매%치체생물합성억제제%치체갑기화매억제제
Sterol%Sterol methyl transferase%Sterol bio-synthesis inhibitor%Sterol methylatied enzyme inhibitors
目的:研究甾体甲基化转移酶。方法:从γ-oryzanol提取的cycloartenol和 24（28）-methylenecycloartenol为初始原料合成目标化合物。结果:成功地合成了11个甾体衍生物。结论:目标化合物均经HPLC 纯化；结构均经NMR和GC/MS确证，方法简便易行。
目的:研究甾體甲基化轉移酶。方法:從γ-oryzanol提取的cycloartenol和 24（28）-methylenecycloartenol為初始原料閤成目標化閤物。結果:成功地閤成瞭11箇甾體衍生物。結論:目標化閤物均經HPLC 純化；結構均經NMR和GC/MS確證，方法簡便易行。
목적:연구치체갑기화전이매。방법:종γ-oryzanol제취적cycloartenol화 24（28）-methylenecycloartenol위초시원료합성목표화합물。결과:성공지합성료11개치체연생물。결론:목표화합물균경HPLC 순화；결구균경NMR화GC/MS학증，방법간편역행。
To study on sterol methytranferase enzyme. METHODS:Target compounds were synthesized from cycloartenoland 24(28)-methylenecycloartenol extracted from γ-oryzanol. RESULTS: 11 sterol derivatives were successfully synthesized. CONCLUSIONS:The target compounds were purified by HPLC and their structures were confirmed by NMR and GC/MS. The methods are simple and operable.
