CAJ | 학술논문

对30例正常人（正常对照组）及60例原发性高血压（EH）患者（EH组，其中轻度EH33例、中度27例）进行用药前后尿α1-微球蛋白（α1-MG），β2-微球蛋白（β2-MG），转铁蛋白测定。结果发现：轻度EH组β2-MG、α1-MG明显高于对照组（P＜0.01）；中度EH组β2-MG、α1-MG、转铁蛋白明显高于轻度EH组和对照组（P＜0.01，P＜0.001）；应用氨氯地平治疗后，EH组尿β2-MG、α1-MG、转铁蛋白均较治疗前明显降低（P＜0.01，P＜0.001）。认为尿β2-MG、α1-MG、转铁蛋白检测能较早识别高血压肾脏损害，氨氯地平在降压的同时预防或延缓肾脏损害的发生发展。
대30례정상인（정상대조조）급60례원발성고혈압（EH）환자（EH조，기중경도EH33례、중도27례）진행용약전후뇨α1-미구단백（α1-MG），β2-미구단백（β2-MG），전철단백측정。결과발현：경도EH조β2-MG、α1-MG명현고우대조조（P＜0.01）；중도EH조β2-MG、α1-MG、전철단백명현고우경도EH조화대조조（P＜0.01，P＜0.001）；응용안록지평치료후，EH조뇨β2-MG、α1-MG、전철단백균교치료전명현강저（P＜0.01，P＜0.001）。인위뇨β2-MG、α1-MG、전철단백검측능교조식별고혈압신장손해，안록지평재강압적동시예방혹연완신장손해적발생발전。
To study the changes of microglobin and transferrin in essentialhypertensive patients and the effect of amlodipine therapy，the concentration of urinary β2-MG，α1-MG and transferrin in 60 essential hypertensive patients and 30 normal persons were measured before and after amlodipine treatment.The result showed that the concentration of urinary β2-MG，α1-MG and transferrin in mild and moderate EH group were significantly higher than that in the control group（P＜0.01）and were significantly lower after amlodipine treatment than that before treatment （P＜0.01，P＜0.001）.This suggestS that cletation of urinary β2-MG，α1-MG and transferrin may identify hypertensive kidney injury earlier.Amlodipine can protect and prevent the occurence and Progression of kidney injury besides its antihypertensive effect.